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Suboxone (buprenorphine/naloxone) is a drug. Instead, follow the ‘rule of 15’ and wait 15 minutes before and after. Suboxone, a combination of buprenorphine and. Web find patient medical information for suboxone sublingual on webmd including its uses, side effects and safety, interactions,. Web suboxone sublingual film can cause serious side effects, including: Web you shouldn’t take suboxone right after you eat. What to ask your doctor. Here's what you should know.