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As an amazon associate, we may earn commissions from qualifying. Web the short answer is yes, melatonin supplements do expire. However, the amount of time it is considered effective may vary. Web expired melatonin is not typically dangerous to consume. However, it may be less effective in its intended purpose of. Web the short answer is yes, melatonin does expire. Many people rely on melatonin gummies to help them get a good night's sleep. However, this doesn’t pose any danger. If you accidentally eat expired melatonin gummies, you may not get the sleep benefits of. But a recent study finds that these.