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Web the short answer is yes, melatonin supplements do expire. Web what happens if you take expired melatonin? However, this doesn’t pose any danger. Web however, various factors such as stress, irregular sleep patterns, and exposure to too much artificial light can disrupt the. Understanding the shelf life and potency of melatonin over time can help. Web will it still be safe and effective? Web the biggest issue with expired melatonin isn’t that it becomes harmful but rather that it loses its effectiveness. Taking expired melatonin is not advised, as the potency of the.